| 08:30 - 10:00 |
New levels of dysregulation in cancer: miRNA,
metabolism
/ Role of
systems biology
Chair: W. Kolch (Glasgow), R.
Schäfer (Berlin)
W. Kolch (Glasgow): Systems Biology in
Cancer Research
A.-L. Børresen-Dale
(Oslo): Exploring the
systems biology/pathology of breast cancer
N. Eckstein
(Bonn): Hyperactivation of the insulin-like growth factor
receptor 1 signaling pathway is an essential event for
cisplatin resistance of ovarian cancer cells
A. Gross (Bern):
A survey of the microRNAome related to RAS oncogene-mediated
transformation
|
| 10:00 |
Coffee break
|
| 10:30 - 12:00 |
Ageing and cellular senescence
Chair:
B. Kaina (Mainz), M. Lipp (Berlin)
A. Lechel (Ulm):
Telomere dysfunction and DNA damage checkpoints in aging and
cancer
P. Boukamp (Heidelberg): Skin: a model for human
aging
F. Köpper (Göttingen): The kinase MAPKAP-12 is an
early responder to ultraviolet irradiation
B. Kaina
(Mainz): DNA double strand break repair in the
O6-alkylguanine response: implications for tumor
chemotherapy
|
| 12:00 - 13:00 |
Lunch |
| 13:00 - 14:30 |
Molecular diagnostics, biomarkers, rational
therapy
Chair: R. Moll (Marburg), R. Engers
(Düsseldorf)
P.D.P. Pharoah (Cambridge): The clinical
significance of polygenic susceptibility to breast cancer
A. Meindl (Munich): Low risk variants and mutations with
moderate penetrance -Can they improve risk assessment in
breast cancer?
K. Mengele (Munich): Expression of Y-box
binding protein YB-1 identifies a subgroup of high-risk
breast cancer patients benefiting from rapidly cycled
high-dose tandem adjuvant chemotherapy
J. Wenzel
(Berlin): Inhibition of breast cancer metastasis by dual
liposomes disturbing the tumour cell-platelet interaction in
vivo
|
| 14:30 - 16:00 |
Tumor models
Chair: I.
Fichtner (Berlin), P. Angel (Heidelberg)
D.J. Jerry
(Amherst): Defining mechanisms of risk and resistance to
mammary tumors using p53-deficient mice
K.-P. Janssen (München):
Mouse models for colorectal cancer: solving a progression
puzzle
S. Müller (Berlin): Establishment of an orthotopic
kidney tumor model using non invasive imaging techniques
R.
Savai (Gießen): Evaluation of angiogenesis using
micro-computed tomography in a xenograpft mouse model of
lung cancer
|
| 16:00 - 18:15 |
Poster Session 2 |
| 18:15 - 19:15 |
AEK Member Assembly |
| from 20:00 |
Dinner
Piazza Rossa Alexanderplatz (near Town Hall,
“Rotes Rathaus”)
|
